{"id":1283,"date":"2022-01-01T09:30:55","date_gmt":"2022-01-01T01:30:55","guid":{"rendered":"https:\/\/intelligent-shop.com\/shop\/?post_type=product&p=1283"},"modified":"2024-01-26T02:13:21","modified_gmt":"2024-01-25T18:13:21","slug":"innovance-nmn%e7%a8%80%e6%9c%89%e4%ba%ba%e5%8f%83%e7%9a%82%e8%8b%b7ck-%e6%9c%ac%e7%b6%b2%e5%ba%97%e6%98%af%e5%bb%a0%e6%96%b9%e7%9a%84%e5%ae%98%e7%b6%b2-%e4%bf%9d%e8%ad%89%e5%8e%9f%e8%a3%9d","status":"publish","type":"product","link":"https:\/\/intelligent-shop.com\/shop\/product\/innovance-nmn%e7%a8%80%e6%9c%89%e4%ba%ba%e5%8f%83%e7%9a%82%e8%8b%b7ck-%e6%9c%ac%e7%b6%b2%e5%ba%97%e6%98%af%e5%bb%a0%e6%96%b9%e7%9a%84%e5%ae%98%e7%b6%b2-%e4%bf%9d%e8%ad%89%e5%8e%9f%e8%a3%9d\/","title":{"rendered":"InnoVance NMN+\u7a00\u6709\u4eba\u53c3\u7682\u82f7CK \u2013 \u672c\u7db2\u5e97\u662f\u5ee0\u65b9\u7684\u5b98\u7db2, \u4fdd\u8b49\u539f\u88dd\u6b63\u8ca8"},"content":{"rendered":"

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\"\"<\/p>\n

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CK\u7684\u751f\u7269\u8f49\u5316:<\/strong>\u00a0\u9176\u89e3\u6cd5\u5236\u5099CK
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\"\"<\/p>\n

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\u8a98\u5c0e\u764c\u7d30\u80de\u51cb\u4ea1<\/strong>
\nCK\u5c0d\u4eba\u5375\u5de2\u764c\u7d30\u80deCAOV3\u5177\u6709\u7d30\u80de\u6bd2\u6027\u4f5c\u7528\uff1b\u9019\u7a2e\u4f5c\u7528\u662f\u901a\u904e\u7d30\u80de\u51cb\u4ea1\u5be6\u73fe\u7684\uff1b \u7d30\u80de\u51cb\u4ea1\u5305\u62ecCaspase-8\u6fc0\u6d3b\u7684\u819c\u53d7\u9ad4\u9014\u5f91\u548cCaspase-9\u6fc0\u6d3b\u7684\u7dda\u7c92\u9ad4\u9014\u5f91\u3002<\/p>\n

\u4e2d\u665a\u671f\u809d\u764c\u53ca\u8853\u5f8c\u5fa9\u767c\u8f49\u79fb\u6027\u809d\u764c\u76ee\u524d\u4ecd\u7136\u7f3a\u4e4f\u6709\u6548\u6cbb\u7642\u624b\u6bb5\u3002\u539f\u4eba\u8518\u4e8c\u9187(protopanoxadiol, PPD) \u53ca\u4eba\u8518\u7682\u82f7 Compound K\u662f\u4e8c\u9187\u578b\u4eba\u8518\u7682\u82f7\u5728\u9ad4\u5167\u7684\u4ee3\u8b1d\u7522\u7269\u3002\u8fd1\u5e74\u4f86\u591a\u9805\u7814\u7a76\u767c\u73fe\u9019\u5169\u7a2e\u5929\u7136\u7522\u7269\u53ef\u901a\u904e\u8a98\u5c0e\u7d30\u80de\u51cb\u4ea1\u3001\u6291\u5236\u7d30\u80de\u589e\u6b96\u3001\u6291\u5236\u8840\u7ba1\u751f\u6210\u3001\u6291\u5236\u8f49\u79fb\u7b49\u6a5f\u5236\u5c0d\u591a\u7a2e\u816b\u7624\u767c\u63ee\u6291\u7624\u6548\u61c9\u3002\u5176\u4e2d\u5c0d\u809d\u7d30\u80de\u809d\u764c\u7684\u4f5c\u7528\u7814\u7a76\u8f03\u591a\uff0c\u6291\u764c\u6548\u679c\u5c24\u70ba\u7a81\u51fa\u3002<\/p>\n

\u7d93\u65e5\u672c\u7814\u7a76\u5831\u544a\uff0c\u4eba\u8518\u63d0\u53d6\u7269\u5c0d\u80c3\u764c\u548c\u5927\u8178\u764c\u5747\u6709\u4e00\u5b9a\u7684\u7642\u6548\uff0c\u5c0d\u65bc\u767d\u8840\u7403\u6e1b\u5c11\u8005\uff0c\u53ef\u770b\u5230\u767d\u8840\u7403\u8207\u6dcb\u5df4\u7403\u589e\u52a0\u3002\u52d5\u7269\u5be6\u9a57\u4ea6\u8b49\u660e\uff0c\u4eba\u8518\u63d0\u53d6\u7269\u6709\u4fdd\u809d\u4f5c\u7528\uff0c\u53ef\u63d0\u9ad8\u514d\u75ab\u529f\u80fd\u548c\u6297\u7a81\u8b8a\u4f5c\u7528\uff0c\u4e26\u5177\u6709\u6291\u5236\u816b\u7624\u751f\u9577\u7684\u529f\u80fd\u3002\u6b64\u5916\u8207\u6297\u764c\u5316\u7642\u85e5\u7269\u5408\u7528\uff0c\u53ef\u4ee5\u63d0\u9ad8\u7642\u6548\u3001\u964d\u4f4e\u5316\u7642\u85e5\u7269\u7684\u6bd2\u526f\u4f5c\u7528\u3002 \u81f3\u6b64\uff0c\u4eba\u8518\u6297\u764c\u7684\u795e\u79d8\u9762\u7d17\u5df2\u88ab\u63ed\u958b\uff0c\u8fd1\u4e8c\u5341\u5e74\u4f86\u6709\u95dc\u4eba\u8518\u6297\u764c\u65b9\u9762\u8ad6\u6587\u4e0d\u4e0b\u767e\u7bc7\uff0c\u4e2d\u570b\u5927\u9678\u5df2\u6709\u591a\u7a2e\u4eba\u8518\u63d0\u53d6\u7269\u88ab\u5217\u70ba\u570b\u5bb6\u6297\u764c\u65b0\u85e5\uff0c\u97d3\u570b\u8207\u65e5\u672c\u3001\u52a0\u62ff\u5927\u4e5f\u7a4d\u6975\u7684\u958b\u767c\u4ee5\u7a00\u6709\u4eba\u8518\u7682\u82f7\u70ba\u4e3b\u7684\u6297\u764c\u65b0\u85e5\uff0c\u9810\u8a08\u4e0d\u4e45\u5c07\u6709\u65b0\u85e5\u554f\u4e16\u3002 \u764c\u75c7\u4e4b\u6240\u4ee5\u6050\u6016\uff0c\u5728\u65bc\u5176\u589e\u751f\u7e41\u6b96\u7684\u80fd\u529b\u8207\u901f\u5ea6\u76f8\u7576\u9a5a\u4eba\uff0c\u8907\u88fd\u7d30\u80de\u7684\u80fd\u529b\u6bd4\u6b63\u5e38\u7d30\u80de\u5feb\u4e0a\u597d\u5e7e\u500d\u3002<\/p>\n

\u7d30\u80de\u8907\u88fd\u53ef\u5206\u70ba\u56db\u500b\u9031\u671f\uff1a<\/b><\/p>\n

\"\"<\/p>\n

1) G1\uff1a<\/strong>\u7d30\u80de\u8907\u88fd\u6e96\u5099\u671f
\n2) S\uff1a<\/strong>\u7d30\u80deDNA\u5408\u6210\u671f
\n3) G2\uff1a<\/strong>\u7d30\u80de\u86cb\u767d\u8cea\u5408\u6210\u671f
\n4) M\uff1a<\/strong>\u7d30\u80de\u5206\u88c2\u671f<\/p>\n

Apoptosis\uff1a<\/strong>\u7d30\u80de\u63a1\u81ea\u6bba\u5f0f\u9010\u4e00\u6162\u6162\u51cb\u4ea1, \u00a0\u7d30\u80de\u8907\u88fd\u53ef\u5206\u70ba\u56db\u500b\u9031\u671f\uff1a
\n1) G0\uff1a<\/strong>\u7d30\u80de\u4f11\u6b62\u671f
\n2) G1\uff1a<\/strong>\u7d30\u80de\u8907\u88fd\u6e96\u5099\u671f
\n3) S\uff1a<\/strong>\u7d30\u80deDNA\u5408\u6210\u671f
\n4) G2\uff1a<\/strong>\u7d30\u80de\u86cb\u767d\u8cea\u5408\u6210\u671f
\n5) M\uff1a<\/strong>\u7d30\u80de\u5206\u88c2\u671f \u4eba\u53c3\u7682\u82f7\u6291\u5236\u764c\u7d30\u80de\u7684\u6a5f\u5236\uff1a\u6291\u5236\u764c\u7d30\u80de\u7684\u57fa\u56e0\u8907\u88fd<\/p>\n

\"\"<\/p>\n

\u764c\u7d30\u80de\u4e2d\u6709\u4e00\u7a2eP-\u7cd6\u86cb\u767d( P-Glycoprotein)\uff0c\u53ef\u5c07\u5316\u7642\u85e5\u7269\u6392\u51fa\u9020\u6210\u764c\u7d30\u80de\u5c0d\u5316\u5b78\u85e5\u7269\u7522\u751f\u6297\u85e5\u6027\u3002 \u7a00\u6709\u4eba\u8518\u7682\u82f7CK\u53ef\u6291\u5236\u764c\u7d30\u80de\u7684P-\u7cd6\u86cb\u767d\uff0c\u589e\u52a0\u764c\u7d30\u80de\u5c0d\u85e5\u7269\u7684\u654f\u611f\u6027\u3002<\/p>\n

\"\"<\/p>\n

\u5927\u91cf\u79d1\u5b78\u7814\u7a76\u8207\u81e8\u5e8a\u89c0\u5bdf\u8b49\u660e\uff1a\u2460\u7a00\u6709\u4eba\u53c3\u7682\u82f7\u53ef\u4ee5\u963b\u65b7\u764c\u7d30\u80de\u7684G1\u671f\uff0c\u5f15\u8d77\u764c\u7d30\u80de\u51cb\u4ea1\u3002\u2461\u8207\u5316\u653e\u7642\u5408\u4f75\u4f7f\u7528\u53ef\u964d\u4f4e\u5316\u653e\u7642\u526f\u4f5c\u7528\u3002\u2462\u964d\u4f4e\u5316\u7642\u85e5\u7269\u7684\u6297\u85e5\u6027\u800c\u63d0\u5347\u5316\u7642\u4e4b\u529f\u6548\u3002\u2463\u63d0\u5347\u514d\u75ab\u529b\u6bba\u6b7b\u6b98\u5b58\u7684\u764c\u7d30\u80de\u3002\u2464\u764c\u75c7\u5fa9\u767c\u6a5f\u7387\u660e\u986f\u964d\u4f4e\u3002\u2465\u63d0\u5347\u764c\u60a3\u7684\u751f\u6d3b\u8cea\u91cf\uff0c\u2466\u5ef6\u9577\u75c5\u60a3\u7684\u5b58\u6d3b\u671f\u3002\u2467\u5c0d\u5404\u7a2e\u764c\u75c7\u5747\u6709\u986f\u8457\u7684\u8f14\u52a9\u7642\u6548<\/p>\n

\"\"<\/p>\n

\u6297\u76ae\u819a\u8870\u8001<\/strong>
\n\u96a8\u7740\u5e74\u9f61\u589e\u9577\u76ae\u819a\u8b8a\u5f97\u4e7e\u71e5\u3001\u51fa\u73fe\u76ba\u7d0b,\u8207\u76ae\u819a\u7d44\u7e54\u4e2d\u900f\u660e\u8cea\u9178 (HA )\u7684 \u6e1b\u5c11\u6709\u5bc6\u5207\u95dc\u4fc2 \u3002\u4ee5 HaCaT\u7d30\u80de\u4f5c\u70ba\u6a21\u578b\u7814\u7a76, \u5728\u57fa\u56e0\u6c34\u5e73\u7814\u7a76 CK \u5c0d\u5ef6\u7de9\u76ae\u819a\u8001\u5316\u7684\u6a5f\u5236, \u7d50\u679c\u767c\u73fe\u7d30\u80de\u7d93 CK \u4f5c\u7528\u5f8c, \u900f\u660e\u8cea\u9178\u5408\u6210\u9176 2(HAS2) \u57fa\u56e0\u7684\u8b8a\u5316\u6700\u660e\u986f \u3002 1 \u03bcmo l L-1 CK \u5b75\u80b2 24 h, HA \u8868\u9054\u91cf\u5f9e 72.6 ng mL-1\u589e\u52a0\u5230 238.7 ng mL-1 \u3002\u88f8\u9f20\u76ae\u819a\u8a66\u9a57 \u8b49\u5be6, CK \u53ef\u986f\u8457\u589e\u52a0\u8868\u76ae\u548c\u4e73\u7a81\u72c0\u771f\u76ae\u4e2d\u7684 HA \u542b\u91cf, \u8868\u76ae\u539a\u5ea6\u660e\u986f\u589e\u52a0, \u5c40\u90e8\u4f7f\u7528 CK \u53ef\u4ee5\u5ef6\u7de9\u76ae\u819a\u51fa\u73fe\u4e7e\u71e5\u3001 \u76ba\u7d0b\u7b49\u8001\u5316\u73fe\u8c61\u3002<\/p>\n

\u6297\u904e\u654f<\/strong>
\n\u5728\u6291\u5236 RAW 264.7\u7d30\u80de\u5408\u6210\u524d\u5217\u817a\u7d20 E2 \u53ca\u91cb\u653e NO \u5be6\u9a57\u4e2d , CK \u7684\u6291\u5236\u7387\u662f\u6c2e\u5353\u65af\u6c40\u7684 2.6\u500d\u3002\u4f46\u662f CK \u4e26\u4e0d\u6291\u5236\u900f\u660e\u8cea\u9178\u9176\u7684\u6d3b\u6027\uff0c\u4e5f\u4e0d\u6e05\u9664\u6d3b\u6027\u6c27\uff0c\u6240\u4ee5CK\u7684\u6297\u904e\u654f\u4f5c\u7528\u53ef\u80fd\u662f\u901a\u904e\u7a69\u5b9a\u7d30\u80de\u819c\u4f86\u5be6\u73fe\u7684\u3002<\/p>\n

\u6297\u708e<\/strong>
\nWestern blotting\u5206\u6790, CK\u4e0b\u8abf\u4e86 ERK \u548c Art\u86cb\u767d\u7684\u8868\u9054 \uff0c\u5f9e\u800c\u963b\u65b7\u4e86 NF-\u03baB\u7684\u6d3b\u6027, \u540c\u6642\u6291\u5236\u4e86 TPA \u8a98\u5c0e\u7684 cox-2\u57fa\u56e0\u6fc0\u6d3b\u7269 AP-1\u7684\u6d3b\u6027, \u6700\u7d42\u6291\u5236 COX-2\u7684\u8868\u9054\uff0c\u4e26\u4e14CK\u80fd\u6709\u6548\u6291\u5236 TPA \u8a98\u5c0e\u7522\u751f\u7684 PGE2 (\u524d\u5217\u817a\u7d20 E2), \u4f7f\u5176\u6062\u5fa9\u5230\u6b63\u5e38\u6c34\u5e73\uff0c\u5f9e\u800c\u9054\u5230\u4e86\u6297\u708e\u548c\u6291\u5236\u816b\u7624\u589e\u751f\u7684\u76ee\u7684 \u3002<\/p>\n

\u4fdd\u809d\u4f5c\u7528<\/strong>
\n\u9ad4\u5167\u5916\u8a66\u9a57\u986f\u793a CK \u5177\u6709\u6bd4\u4e00\u7dda\u6162\u6027\u809d\u708e\u6cbb\u7642\u85e5\u7269\u6c34\u98db\u858a\u7d20\u548c\u806f\u82ef\u96d9\u916f\u66f4\u597d\u7684\u809d\u640d\u50b7\u4fdd\u8b77\u4f5c\u7528 ,\u662f\u4e00\u500b\u5f88\u597d\u7684\u6cbb\u7642\u809d\u708e\u548c\u4fdd\u809d\u8b77\u809d\u7684\u5019\u9078\u85e5\u7269\u3002<\/p>\n

\u795e\u7d93\u640d\u50b7\u4fee\u5fa9<\/strong>
\nTohda\u7b49\u4ee5 Abeta(25-35)\u8a98\u5c0e\u7684\u65e9\u8001\u6027\u75f4\u5446\u00a0(Alzheimer\u2019 s disease, AD)\u5c0f\u9f20\u6a21\u578b\u7814\u7a76 CK \u5c0d\u8a18\u61b6\u640d\u50b7\u7684\u4fee\u5fa9\u4f5c\u7528\u3002\u7d50\u679c\u986f\u793a CK \u80fd\u660e\u986f\u63d0\u9ad8\u5927\u8166\u76ae\u5c64\u548c\u6d77\u99ac\u8ff4\u8def\u4e2d NF-H \u548c\u7a81\u89f8\u7d20\u6c34\u5e73, \u4fc3\u9032\u8ef8\u7a81\u4f38\u5c55, \u9006\u8f49\u8ef8\u7a81\u795e\u7d93\u708e\u6027\u840e\u7e2e\u53ca\u7a81\u89f8\u7f3a\u5931 ,\u5f9e\u800c\u6539\u5584AD\u60a3\u8005\u7684\u8a18\u61b6\u969c\u7919\u3002<\/p>\n

\u6291\u5236\u6297\u767c\u708e\u7684\u4f5c\u7528<\/strong>
\n\u6839\u64da\u4e2d\u570b\u79d1\u5b78\u5bb6\u672c\u7bc7\u5be6\u9a57\u8b49\u5be6\u4eba\u8518\u7682\u82f7CK\u4e0d\u50c5\u53ef\u4ee5\u4fc3\u9032\u5927\u8178\u708e\u9032\u5c55\u7684\u6062\u5fa9\u548c\u6291\u5236\u6297\u767c\u708e\u7684\u7522\u751f\uff0c\u4e5f\u53ef\u4ee5\u8abf\u7bc0\u5de8\u566c\u7d30\u80de\u548c\u4fc3\u9032\u767c\u708e\u6027\u56e0\u5b50\u7684\u7522\u751f\uff0c\u9032\u800c\u5411\u4e0b\u8abf\u7bc0\u6d3b\u5316\u8def\u5f91\u3002
\n\u4eba\u8518\u7682\u82f7CK\u53ef\u85c9\u7531\u8abf\u63a7NF-\u03baB\u8a0a\u865f\u50b3\u905e\u8def\u5f91\u4f86\u6291\u5236\u7531\u8461\u805a\u91a3\u786b\u9178\u9209DSS\u6240\u8a98\u767c\u7684\u5927\u8178\u708e\u53cd\u61c9 \u690d\u7269\u6027\u5316\u5408\u7269\uff0c\u4f8b\u5982\u4eba\u8518\u7682\u82f7CK\u6216\u662f\u751f\u7269\u9e7c\uff08BBR\uff09\uff0c\u5177\u6297\u6c27\u5316\u548c\u6297\u767c\u708e\u7684\u6027\u8cea\uff0c\u76ee\u524d\u5df2\u88ab\u8996\u70ba\u7528\u65bc\u9810\u9632\u53ca\u6cbb\u7642\u764c\u75c7\u548c\u514d\u75ab\u767c\u708e\u4e0a\u7684\u6709\u6548\u8f14\u52a9\u7528\u85e5\u3002TNBS\u6240\u8a98\u767c\u7684\u5927\u8178\u708e\u640d\u50b7\u3002\u7136\u800c\u4eba\u8518\u7682\u82f7\u7684\u6297\u767c\u708e\u4f5c\u7528\u6a5f\u5236\u81f3\u4eca\u5c1a\u672a\u6e05\u695a\uff0c\u5c24\u5176\u662f\u4eba\u8518\u7682\u82f7CK\u3002 \u672c\u7bc7\u4f7f\u7528Dextran Sulfate Sodium\uff08DSS\uff09 \u8a98\u767c\u5c0f\u9f20\u5927\u8178\u708e\uff0c\u6e2c\u8a66\u5927\u8178\u7d44\u7e54\u4e2d\u8178\u9053\u7684\u5b8c\u6574\u6027\u3001\u4fc3\u767c\u708e\u6fc0\u7d20\u7684\u7522\u751f\u53ca\u8a0a\u606f\u50b3\u905e\u8def\u5f91\u7b49\u81e8\u5e8a\u53c3\u6578\u3002\u5728\u8f15\u5ea6\u548c\u91cd\u5ea6\u5169\u7d44\u5927\u8178\u708e\u5c0f\u9f20\u7684\u7d50\u8178\u7d44\u7e54\u548c\u8840\u6db2\u4e2d\uff0c\u4eba\u8518\u7682\u82f7\u82f7CK\u548cBBR\uff08\u8178\u708e\u6cbb\u7642\u5291\uff0c\u505a\u70ba\u6b63\u5411\u63a7\u5236\u7d44\uff09\u80fd\u6e1b\u7de9\u5927\u8178\u708e\u7d44\u7e54\u75c5\u7406\u5b78\u640d\u50b7\uff0c\u6539\u5584\u9aa8\u9ad3\u904e\u6c27\u5316\u9176\uff08MPO\uff09\u6d3b\u6027\uff0c\u964d\u4f4e\u4fc3\u767c\u708e\u6fc0\u7d20\u7684\u7522\u751f\uff0c\u5982IL-6 \u3001IL-1\u03b2\u3001 TNF-\u03b1\uff0c\u4ee5\u53ca\u589e\u52a0\u6297\u767c\u708e\u56e0\u5b50IL- 10\u7684\u7522\u751f\u3002<\/p>\n

\u5c0d\u773c\u90e8\u75be\u75c5\u7684\u4f5c\u7528 \u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027 Age-related macular degeneration (AMD)<\/strong>
\nAMD\u662f\u767c\u9054\u570b\u5bb650\u6b72\u4ee5\u4e0a\u4eba\u7fa4\u8996\u529b\u969c\u7919\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00 \u3002AMD\u9010\u6f38\u7834\u58de\u9ec3\u6591\uff08\u9760\u8fd1\u8996\u7db2\u819c\u4e2d\u5fc3\u7684\u8272\u7d20\u5340\uff09\u4e26\u640d\u5bb3\u4e2d\u592e\u8996\u529b\u3002\u8108\u7d61\u819c\u65b0\u751f\u8840\u7ba1\u4e3b\u8981\u7531\u8840\u7ba1\u751f\u6210\u7d30\u80de\u56e0\u5b50\u5f15\u8d77\uff0c\u5982\u8840\u7ba1\u5167\u76ae\u751f\u9577\u56e0\u5b50 (VEGF Vascular endothelial growth factor)\uff0c\u662f\u65b0\u751f\u8840\u7ba1\u6027 AMD \u7684\u4e3b\u8981\u4fc3\u6210\u56e0\u7d20\uff0c\u4f46AMD\u4e5f\u8207\u6c27\u5316\u61c9\u6fc0\u589e\u52a0\u3001\u708e\u75c7\u548c\u86cb\u767d\u9176\u9ad4\u6216\u6eb6\u9176\u9ad4\u529f\u80fd\u53d7\u640d\u6709\u95dc\uff0c\u5c0e\u81f4\u5f62\u6210\u7d30\u80de\u5167\u548c\u7d30\u80de\u5916\u6c89\u7a4d\u7269\u3002\u76ee\u524d\uff0c\u4f7f\u7528\u55ae\u514b\u9686\u6297\u9ad4\u6216\u9069\u9ad4\u7684\u73bb\u7483\u9ad4\u5167\u6297 VEGF \u6cbb\u7642\u662f\u65b0\u751f\u8840\u7ba1\u6027AMD\u7684\u4e3b\u8981\u6cbb\u7642\u9078\u64c7\u3002 BM \u662f\u4f4d\u65bc\u8996\u7db2\u819c\u548c\u8108\u7d61\u819c\u4e4b\u9593\u7684\u4e94\u5c64\u7d30\u80de\u5916\u57fa\u8cea (ECM extracellular matrix) \u3002BM(Bruch\u2019s membrane)\u4fc3\u9032\u8108\u7d61\u819c\u6bdb\u7d30\u8840\u7ba1\u548c RPE \u4e4b\u9593\u71df\u990a\u7269\u8cea\u548c\u4ee3\u8b1d\u5ee2\u7269\u7684\u4ea4\u63db\uff0c\u4e26\u652f\u6301 RPE \u7d30\u80de\u7684\u5206\u5316\u548c\u7c98\u9644\u3002\u7814\u7a76\u8868\u660e\uff0c\u8207\u5e74\u9f61\u76f8\u95dc\u7684 BM \u589e\u539a\u3001\u8102\u8cea\u548c\u86cb\u767d\u8cea\u6c89\u7a4d\u7269\u7684\u7a4d\u7d2f\u4ee5\u53ca\u904b\u8f38\u80fd\u529b\u964d\u4f4e\u8207 AMD \u7684\u767c\u75c5\u6a5f\u5236\u6709\u95dc\uff0c\u56e0\u6b64\uff0c\u5df2\u7d93\u5236\u5b9a\u4e86\u6539\u5584\u8de8 BM \u904b\u8f38\u7684\u6cbb\u7642\u65b9\u6cd5\u4ee5\u9810\u9632\u6216\u6cbb\u7642 AMD\u3002 Lee\u7b49\u4eba\u4f7f\u7528\u5f9e\u4eba\u985e\u4f9b\u9ad4\u773c\u4e2d\u7372\u5f97\u7684 Bruch \u8108\u7d61\u819c\u9032\u884c\u4e86\u6709\u8da3\u7684\u5be6\u9a57\uff0c\u4ee5\u8a55\u4f30\u4eba\u53c3\u5c0d BM \u7684\u6709\u76ca\u4f5c\u7528\u3002\u6e2c\u91cf\u4e86\u7528\u9ad8\u9e97\u7d05\u53c3\u63d0\u53d6\u7269\uff08KRGE\uff0c P. ginseng \uff09\u8655\u7406 24 \u5c0f\u6642\u5f8c\u7570\u786b\u6c30\u9178\u87a2\u5149\u7d20 (FITC Fluorescein isothiocyanate) \u6a19\u8a18\u7684\u767d\u86cb\u767d\u7684\u6c34\u529b\u50b3\u5c0e\u7387\u548c\u64f4\u6563\u50b3\u8f38\u7684\u8b8a\u5316\uff1b\u4eba\u53c3\u7682\u82f7Rb1; \u8907\u5408\u7269K; Compound K (CK) is a secondary ginsenoside)\uff1b\u6216\u542b\u6709\u4eba\u53c3\u7682\u82f7 Rb1\u3001Rb2\u3001Rc\u3001Rd\u3001Rg1\u3001Rg2\u3001Re \u548c Rf \u7684\u4eba\u53c3\u7682\u82f7\u6df7\u5408\u7269\u3002\u4ed6\u5011\u89c0\u5bdf\u5230 KRGE\u3001\u4eba\u53c3\u7682\u82f7 Rb1\u63d0\u9ad8\u4e86\u4eba\u985e BM \u7684\u904b\u8f38\u80fd\u529b, \u548c\u8907\u5408 K \u8655\u7406\u3002 RPE(Retinal pigment epithelium)\u662fBM\u548c\u8996\u7db2\u819c\u5149\u611f\u53d7\u5668 \u4e4b\u9593\u7684\u55ae\u5c64\u8272\u7d20\u7d30\u80de\u3002RPE \u7d30\u80de\u652f\u6301\u8996\u7db2\u819c\u5149\u611f\u53d7\u5668\u7684\u5b8c\u6574\u6027\u548c\u5b58\u6d3b\uff0c\u800c RPE \u7d30\u80de\u6b7b\u4ea1\u662f AMD \u7684\u6a19\u8a8c\u4e4b\u4e00\u3002Betts \u7b49\u5831\u5c0e\u4eba\u53c3\u7682\u82f7Rb1\u5728\u9ad4\u5916\u8a98\u5c0e\u6210\u9ad4 RPE \u7d30\u80de (ARPE-19)\u589e\u6b96\uff0c\u800c\u5b83\u6291\u5236 ARPE-19 \u7d30\u80de\u91cb\u653e VEGF\u3002 \u7e3d\u4e4b\uff0cKRGE\u548c\u4eba\u53c3\u7682\u82f7\u53ef\u4ee5\u901a\u904e\u63d0\u9ad8\u8de8BM\u7684\u8f49\u904b\u80fd\u529b\u6216\u6291\u5236ARPE-19(Adult Retinal Pigment Epithelial cell line-19)\u7d30\u80de\u4e2d\u7684VEGF\u7522\u751f\u4f86\u6e1b\u7de9AMD\u7684\u767c\u75c5\u548c\u9032\u5c55\u3002
\nJ Kim, SY Han, H Min \u2013 \u4eba\u53c3\u7814\u7a76\u96dc\u8a8c, 2020 \u2013 Elsevier<\/p>\n

\u767c\u63ee1+1\u7b49\u65bc\u7121\u9650\u7684\u4fdd\u5065\u4f5c\u7528\u548c\u6297\u8870\u8001\u529f\u80fd<\/strong>
\n\u7531\u897f\u5b89\u7814\u767c\u57fa\u5730\u4ee5\u7368\u5bb6\u9ad8\u6548\u7387\u751f\u7269\u8f49\u5316\u6280\u8853\u5f9e\u591a\u65bc500\u516c\u65a4\u4e09\u4e03\u4eba\u8518\u4e2d\u63d0\u7149\u51fa1\u516c\u65a4\u7684\u7a00\u6709\u4eba\u8518\u7682\u82f7\u8f49\u5316\u7269\u3002
\n\u518d\u914d\u4ee5\u9ad8\u7d14\u5ea699.8% NMN, NMN\u80fd\u5354\u52a9\u7dad\u6301\u4ee3\u8b1d\u529f\u80fd\uff0c\u5c0d\u6297\u7d30\u80de\u8001\u5316\u554f\u984c\u3002\u4eba\u985e\u904e\u4e8625\u6b72\uff0c\u8eab\u9ad4\u4e2d\u7684NAD+\u6703\u8fc5\u901f\u6e1b\u5c11\u4e14\u4e0d\u6703\u518d\u81ea\u7136\u751f\u6210\uff0c\u8b93\u808c\u819a\u8870\u8001\u60c5\u6cc1\u8b8a\u5f97\u66f4\u70ba\u660e\u986f\uff0c\u900f\u904e\u88dc\u5145NMN\uff0c\u53ef\u4ee5\u589e\u52a0NAD+\u7684\u6578\u91cf\uff0c\u9054\u5230\u5ef6\u7de9\u8870\u9000\u7684\u6548\u679c\u3002
\n\u4ee5\u4e0b\u70baNMN\u76848\u500b\u529f\u6548\uff1a<\/strong>
\n\u5354\u52a9\u4fee\u5fa9DNA\u751f\u6210
\n\u6539\u5584\u7c92\u817a\u9ad4\u529f\u80fd, \u63d0\u4f9b\u7d30\u80de\u80fd\u91cf
\n\u7dad\u6301\u76ae\u819a\u3001\u795e\u7d93\u7cfb\u7d71\u904b\u4f5c
\n\u6297\u8840\u7ba1\u8001\u5316
\n\u589e\u52a0\u808c\u8089\u8010\u529b\u548c\u808c\u529b
\n\u964d\u4f4e\u5fc3\u81df\u75c5\u7684\u98a8\u96aa
\n\u964d\u4f4e\u80a5\u80d6\u7684\u98a8\u96aa
\n\u4fdd\u5065\u8eab\u9ad4\u3001\u7dad\u6301\u6d3b\u529b
\nNMN\u548c\u7a00\u6709\u4eba\u8518\u7682\u82f7CK\u5169\u8005\u914d\u5408\u9032\u4e00\u6b65\u63d0\u5347\u8eab\u9ad4\u6d3b\u529b\uff0c\u56de\u5fa9\u9752\u6625, \u52a0\u5f37\u514d\u75ab\u529b\u3002\u767c\u63ee1+1\u7b49\u65bc\u7121\u9650\u7684\u4fdd\u5065\u548c\u6297\u8870\u8001\u529f\u80fd\u3002<\/p>\n

100%\u7f8e\u570b\u5236\u9020<\/strong>, \u6bcf\u6279\u6b21\u7684 InnoVance NMN+CK<\/strong> \u51fa\u5ee0\u6642\uff0c\u90fd\u7d93\u904e\u56b4\u683c\u6e2c\u8a66\u4fdd\u8b49\u4e0d\u542b\u6709\u5bb3\u7269\u8cea, \u4e00\u5207\u7b26\u7f8e\u570b\u98df\u54c1\u548c\u85e5\u54c1\u76e3\u7ba1\u5c40FDA\u76e3\u7ba1\u4e0b\u7684 GMP \u85e5\u5ee0\u6240\u9700\u6a19\u6e96\u3002<\/p>\n

\u6bcf\u7c92\u542b\u6709 75mg NMN + 10 mg \u7a00\u6709\u4eba\u53c3\u7682\u82f7CK , \u6bcf\u6a3d60\u7c92 ; \u5171 4500 mg NMN + 600 mg \u7a00\u6709\u4eba\u53c3\u7682\u82f7CK \u3002InnoVance<\/strong> \u5c08\u5bb6\u8303\u6559\u6388<\/strong>\u6089\u5fc3\u8abf\u914d, \u9078\u7528NMN 75mgx4 = 300mg\/\u5929; \u7a00\u6709\u4eba\u53c3\u7682\u82f7CK 10mg x 4 = 40 mg\/\u5929\u3002<\/p>\n

\u98df\u7528\u4efd\u91cf:<\/strong> \u9751\u5e74\u4eba\u6bcf\u5929\u65e9\u665a\u5404\u4e00\u7c92\uff0c\u4e2d\/\u8001\u5e74\u4eba\u65e9\u665a\u5404\u5169\u7c92.<\/p>\n

\"\"<\/p>\n

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